abstract：:Sarcomas developing after radiation treatment for primary malignancies of the head and neck are often detected clinically when they are very aggressive. We reviewed the patient demographics and imaging findings in 21 patients with radiation-associated sarcomas (RAS) of the head and neck treated at our institution. Twe...

journal_title：Oral oncology

authors： Debnam JM,Guha-Thakurta N,Mahfouz YM,Garden AS,Benjamin RS,Sturgis EM,Ginsberg LE

更新日期：2012-02-01 00:00:00

abstract：:Cancer invasion induces extracellular matrix remodeling and collagen degradation. The aim of this study was to assess whether serum levels of type I and III collagen degradation products were associated with patient survival in head and neck squamous cell carcinoma (HNSCC). A novel enzyme immunoassay was developed for...

journal_title：Oral oncology

authors： Nurmenniemi S,Koivula MK,Nyberg P,Tervahartiala T,Sorsa T,Mattila PS,Salo T,Risteli J

更新日期：2012-02-01 00:00:00

abstract：:The role of chemotherapy (CHX) in squamous cell carcinoma of the head and neck (SCCHN) has been expanding. Although combination chemotherapy regimens regularly produce significantly high response rates, meta-analyses show little benefit regarding final outcome. One way to improve induction CHX is to improve drug combi...

journal_title：Oral oncology

authors： Sasaki Y,Kjellén E,Ekblad L,Wahlberg P,Mineta H,Wennerberg J

更新日期：2012-01-01 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TILs) are considered to represent immune reactions of the host to a malignant tumor. Programmed death receptor ligand-1 (PD-L1) is a surface protein that blocks the function of T lymphocytes and is expressed on cancer cells. Tumor-associated fibroblasts (TAFs), which influence tumor gro...

journal_title：Oral oncology

authors： Cho YA,Yoon HJ,Lee JI,Hong SP,Hong SD

更新日期：2011-12-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor involved not only in vascular biology but also in carcinogenesis. Results of a study in 2007 suggested salivary ET-1 as a potential biomarker for oral squamous cell carcinoma (OSCC), but a later study showed conflicting results. The purpose of our pilot study was to inve...

journal_title：Oral oncology

authors： Cheng YS,Rees T,Jordan L,Oxford L,O'Brien J,Chen HS,Wong D

更新日期：2011-12-01 00:00:00

abstract：:Lymphatic malformations, traditionally called lymphangiomas, are diseases caused by development errors of the lymphatic system. About 90% of the cases occur within 2years of age, except a few cases which occur in adulthood, and approximately 75% of the lesions are located in the head and neck region. The lesions can g...

journal_title：Oral oncology

authors： Zhou Q,Zheng JW,Mai HM,Luo QF,Fan XD,Su LX,Wang YA,Qin ZP

更新日期：2011-12-01 00:00:00

abstract：:An algorithm was developed to predict lymph node metastasis in patients with oral squamous cell carcinoma. To improve the diagnostic accuracy of lymph node status, we suggest a criterion for the prediction of lymph node status by combining clinical and molecular information. To develop a model to predict lymph node me...

journal_title：Oral oncology

authors： Kim KY,Cha IH

更新日期：2011-11-01 00:00:00

abstract：:Chemotherapeutic regimens incorporating taxanes significantly improve outcomes for patients with squamous cell carcinomas of the head and neck (SCCHN). However, treatment with taxanes is limited by toxicities, including bone marrow suppression and peripheral neuropathies. We proposed that conjugating taxanes to target...

journal_title：Oral oncology

authors： Galer CE,Sano D,Ghosh SC,Hah JH,Auzenne E,Hamir AN,Myers JN,Klostergaard J

更新日期：2011-11-01 00:00:00

abstract：:Apicidin acts as a potent histone deacetylases (HDAC) inhibitor and the precise mechanism for its anti-tumor activity in human oral squamous cell carcinoma (OSCC) cells has not been examined. The aim of this study was to evaluate the anti-tumor efficacy of apicidin through apoptosis and autophagy in OSCC cells. Cells ...

journal_title：Oral oncology

authors： Ahn MY,Ahn SG,Yoon JH

更新日期：2011-11-01 00:00:00

abstract：:Oral leukoplakia is a potentially malignant disorder that will develop into oral cancer at an estimated rate of 1-2% per year. Aim of the present study is to assess the possible predictive value of DNA ploidy for malignant progression of oral leukoplakia. A cohort of 62 leukoplakia patients was studied and their biops...

journal_title：Oral oncology

authors： Bremmer JF,Brakenhoff RH,Broeckaert MA,Beliën JA,Leemans CR,Bloemena E,van der Waal I,Braakhuis BJ

更新日期：2011-10-01 00:00:00

abstract：:Oral mucositis (OM) is a devasting toxicity associated with cytotoxic cancer therapy. Antrum mucosal protein (AMP)-18 and a synthetic peptide surrogate, exhibit cell protective and mitogenic properties in in vitro and in vivo models of gastrointestinal epithelial cell injury. The mucosal barrier-protective effects may...

journal_title：Oral oncology

authors： Chen P,Lingen M,Sonis ST,Walsh-Reitz MM,Toback FG

更新日期：2011-09-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is characterized by high mortality rates. High incidence of local recurrences in the normal-appearing surgical margins of OSCC patients indicates the existence molecular alterations, including DNA methylation, which could not be detectable by histopathologic analysis. The objective ...

journal_title：Oral oncology

authors： Supic G,Kozomara R,Jovic N,Zeljic K,Magic Z

更新日期：2011-08-01 00:00:00

abstract：:In our previous study, we established an in vitro cellular carcinogenesis model of oral squamous cell carcinoma (OSCC), including a human immortalized oral epithelial cell (HIOEC) and a cancerous cell line (HB96). Microarray analysis showed that the gene encoding Yes-associated protein (YAP) was significantly increase...

journal_title：Oral oncology

authors： Zhang L,Ye DX,Pan HY,Wei KJ,Wang LZ,Wang XD,Shen GF,Zhang ZY

更新日期：2011-08-01 00:00:00

abstract：:The aims of this study were to assess a cohort of patients with head and neck squamous cell carcinoma (HNSCC) for: (1) the prevalence of synchronous distant metastases (DM) as detected by the initial staging by using (18)F-FDG PET/CT, (2) the prevalence of metachronous DM, and (3) the validity of published risk factor...

journal_title：Oral oncology

authors： Haerle SK,Schmid DT,Ahmad N,Hany TF,Stoeckli SJ

更新日期：2011-07-01 00:00:00

abstract：:Oral cancer is a potentially preventable disease due to its association with well-known risk factors and easy detectability. There is a significant deficiency in the awareness of oral cancer and its risk factors among the public. Raising public awareness could effectively contribute to achieving a significant reductio...

journal_title：Oral oncology

authors： Elango KJ,Anandkrishnan N,Suresh A,Iyer SK,Ramaiyer SK,Kuriakose MA

更新日期：2011-07-01 00:00:00

abstract：:We performed a meta-analysis to evaluate the role of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)FDG-PET/CT) in detecting distant metastases and second primary cancers in patients with head and neck cancer (HNC) at staging. Studies about (18)FDG-PET/CT for detecting distant metastase...

journal_title：Oral oncology

authors： Xu GZ,Guan DJ,He ZY

更新日期：2011-07-01 00:00:00

abstract：:We assessed the risk factors associated with surgical site infection (SSI) in 697 patients who underwent major oncological surgery for head-and-neck cancer (HNC). SSIs within 30days were classified as incision, space, or leakage/fistula. Preoperative and operative risk factors for SSIs were assessed by univariate and ...

journal_title：Oral oncology

authors： Lee DH,Kim SY,Nam SY,Choi SH,Choi JW,Roh JL

更新日期：2011-06-01 00:00:00

abstract：:Several reports have indicated that nuclear factor-kappa B (NF-κB) is constitutively activated in a variety of cancer cells including human oral squamous carcinoma cells, and play a key role in their growth and survival. Recent studies report that NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), inhibits proli...

journal_title：Oral oncology

authors： Yasuda A,Kondo S,Nagumo T,Tsukamoto H,Mukudai Y,Umezawa K,Shintani S

更新日期：2011-05-01 00:00:00

abstract：:Early detection of oral cancer is crucial in improving survival rate. Identification and detection of oral potentially malignant disorders (OPMD) allow delivery of interventions to reduce the evolution of these disorders to malignancy. A variety of new and emerging diagnostic aids and adjunctive techniques are current...

journal_title：Oral oncology

authors： Awan KH,Morgan PR,Warnakulasuriya S

更新日期：2011-04-01 00:00:00

abstract：UNLABELLED:Squamous cell carcinoma of the tongue (TSCC) has one of the poorest prognoses of head and neck cancers. This study aims to improve early detection of the disease by identifying salivary biomarkers that can identify a spectrum of patients progressing from high-risk to TSCC. We also examine the mortality of ex...

journal_title：Oral oncology

authors： Korostoff A,Reder L,Masood R,Sinha UK

更新日期：2011-04-01 00:00:00

abstract：:Head and neck squamous cell cancer (HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of this disease. Efforts are ongoing throughout the world to improve early detection and prevention of H...

journal_title：Oral oncology

authors： Sayed SI,Dwivedi RC,Katna R,Garg A,Pathak KA,Nutting CM,Rhys-Evans P,Harrington KJ,Kazi R

更新日期：2011-04-01 00:00:00

abstract：:Prophylactic internal fixation (PIF), with a bone plate in either the anterior (over the section defect) or posterior (on intact cortex) position, has substantially reduced the incidence of fracture at the donor site of the radial osteocutaneous free flap. This study uses the sheep tibia model to compare the effective...

journal_title：Oral oncology

authors： Avery CM,Skidmore M,Peden A,Pan J

更新日期：2011-04-01 00:00:00

abstract：:Osteonecrosis of the jaw (ONJ) is an adverse event that has been reported in patients receiving cancer treatment regimens, including bevacizumab, bisphosphonates, and denosumab. We performed a preliminary open label, prospective phase I-II study in patients treated with bisphosphonate to evaluate the treatment effect ...

journal_title：Oral oncology

authors： Ripamonti CI,Cislaghi E,Mariani L,Maniezzo M

更新日期：2011-03-01 00:00:00

abstract：:We evaluate whether p53-reactivating (p53RA) small molecules induce p53-dependent apoptosis in head and neck squamous cell carcinoma (HNSCC), a question that has not been previously addressed in head and neck cancer. PRIMA-1, CP-31398, RITA, and nutlin-3 were tested in four human HNSCC cell lines differing in TP53 sta...

journal_title：Oral oncology

authors： Roh JL,Kang SK,Minn I,Califano JA,Sidransky D,Koch WM

更新日期：2011-01-01 00:00:00

abstract：:Our previous study demonstrated that overexpression of Id-1 (inhibitor of differentiation/DNA binding) was associated with lymphatic metastasis in human oral squamous cell carcinoma (OSCC). In this study, we further unveiled the association of Id-1 with vascular endothelial growth factor-C (VEGF-C) and peritumoral lym...

journal_title：Oral oncology

authors： Dong Z,Wei F,Zhou C,Sumida T,Hamakawa H,Hu Y,Liu S

更新日期：2011-01-01 00:00:00

abstract：:Indole-3-carbinol (I3C), a naturally occurring phytochemical found in cruciferous vegetables, has received much attention due to its translational potential in cancer prevention and therapy. In this study, we investigated the antitumor effects of OSU-A9, a structurally optimized I3C derivative, in a panel of oral squa...

journal_title：Oral oncology

authors： Weng JR,Bai LY,Omar HA,Sargeant AM,Yeh CT,Chen YY,Tsai MH,Chiu CF

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:A systematic review to establish what evidence is available for swallowing outcomes following IMRT for head and neck cancer. METHODS:Online electronic databases were searched to identify papers published in English from January 1998 to December 2009. Papers were independently appraised by two reviewers for met...

journal_title：Oral oncology

authors： Roe JW,Carding PN,Dwivedi RC,Kazi RA,Rhys-Evans PH,Harrington KJ,Nutting CM

更新日期：2010-10-01 00:00:00

abstract：:The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy. We performed immunohistochemistry to examine MK expression in specimens of adenoid cystic carcinoma (ACC), mucoepidermoid carci...

journal_title：Oral oncology

authors： Ota T,Ota K,Jono H,Fujimori H,Ueda M,Shinriki S,Sueyoshi T,Shinohara M,Ando Y

更新日期：2010-09-01 00:00:00

abstract：:The objective of this study was to analyze the role of adjuvant chemotherapy and prognostic factors in malignant mucosal melanoma of the head and neck (HNMM). Thirty-two patients with mucosal melanoma of the head and neck who received local treatment with or without adjuvant chemotherapy were reviewed. Clinicopatholog...

journal_title：Oral oncology

authors： Ahn HJ,Na II,Park YH,Cho SY,Lee BC,Lee GH,Koh JS,Lee YS,Shim YS,Kim YK,Kang HJ,Ryoo BY,Yang SH

更新日期：2010-08-01 00:00:00

abstract：:To determine the aesthetic and functional outcomes of the most invasive approach to oral cavity/oropharyngeal lesions, the lip-splitting mandibulotomy approach (LSMA), versus the least invasive, the trans-oral approach (TOA). Retrospective paired-cohort study. Thirty-six patients with oral/oropharyngeal cancers treate...

journal_title：Oral oncology

authors： Dziegielewski PT,O'Connell DA,Rieger J,Harris JR,Seikaly H

更新日期：2010-08-01 00:00:00

abstract：:Costimulatory molecules have complementary effects on T-cell activation and their balance may control the development of oral cancer. The aim of this study was to determine the relevance of cytotoxic T-lymphocyte antigen 4 (CTLA-4), CD28 and inducible costimulator (ICOS) polymorphisms in oral squamous cell carcinoma (...

journal_title：Oral oncology

authors： Kämmerer PW,Toyoshima T,Schöder F,Kämmerer P,Kuhr K,Brieger J,Al-Nawas B

更新日期：2010-07-01 00:00:00

abstract：:Systemic chemotherapy is increasingly being used with radiotherapy for the radical treatment of advanced head and neck cancers. Chemotherapy offers modest benefits in the metastatic setting. Platinum containing agents are the most active drugs and form the mainstay of most chemotherapy schedules. In recent years taxan...

journal_title：Oral oncology

authors： Bhide SA,Nutting CM

更新日期：2010-06-01 00:00:00

abstract：:Histone deacetylases (HDACs) are enzymes that are involved in the remodeling of chromatin and play a key role in the epigenetic regulation of gene expression. In addition, the activity of non-histone proteins can be regulated through HDAC-mediated hypoacetylation. In recent years, inhibition of HDACs has emerged as a ...

journal_title：Oral oncology

authors： Iglesias-Linares A,Yañez-Vico RM,González-Moles MA

更新日期：2010-05-01 00:00:00

abstract：:This research aims to give a new insight to the relationship between host local immune response and the biological behaviour of the tumor by evaluating of intratumoral natural killer (NK) cells and tumor necrosis factor-alpha (TNFalpha) expressions in oral squamous cell carcinomas. New paraffin sections of the deepest...

journal_title：Oral oncology

authors： Türkseven MR,Oygür T

更新日期：2010-05-01 00:00:00

abstract：:To determine if socio-economic status (SES) affects the stage at presentation of head and neck cancer (HNC) patients in Ottawa, Canada. To determine if the method of diagnosis affects the stage at presentation in these patients. We obtained data on SES, method of diagnosis, and stage at presentation for patients prese...

journal_title：Oral oncology

authors： Johnson S,Corsten MJ,McDonald JT,Chun J

更新日期：2010-05-01 00:00:00

abstract：:Previous work from our laboratory has demonstrated overexpression of chemokines in head and neck cancer and the utility of targeting these proteins for tumor therapy in a preclinical model. However, the mechanisms involved are unexplored. Through gene expression analysis, we found that expression of vascular endotheli...

journal_title：Oral oncology

authors： Benke EM,Ji Y,Patel V,Wang H,Miyazaki H,Yeudall WA

更新日期：2010-04-01 00:00:00

abstract：:We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngea...

journal_title：Oral oncology

authors： Nguyen NP,Ceizyk M,Vos P,Vinh-Hung V,Davis R,Desai A,Abraham D,Krafft SP,Jang S,Watchman CJ,Ewell L,Hamilton R,Smith-Raymond L

更新日期：2010-04-01 00:00:00

abstract：:Bisphosphonates (BP) have been associated with the occurrence of osteonecrosis of the jaw (ONJ), possibly by causing an excessive bone turnover inhibition. However, little in vivo evidence exists to support this theory. The (99m)Tc-medronate scintigrams of patients with skeletal metastases and BP use (n=40) were indiv...

journal_title：Oral oncology

authors： Van den Wyngaert T,Huizing MT,Fossion E,Vermorken JB

更新日期：2010-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in neoplastic process. miR-24 is localized on chromosome 9q22 and 19p13, regions frequently altered in oral squamous cell carcinoma (OSCC). This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSC...

journal_title：Oral oncology

authors： Lin SC,Liu CJ,Lin JA,Chiang WF,Hung PS,Chang KW

更新日期：2010-03-01 00:00:00

abstract：:Head-and-neck (H&N) tumor re-growth is clinically observed after arrest of anti-EGFR therapies. In the present study, we compared, for a similar dose exposure to anti-EGFR therapies, constant (CS) with tapered (TS) schedules (i.e. progressive dose reduction) for cetuximab, a mAb, and gefitinib, a TKI. Mice bearing CAL...

journal_title：Oral oncology

authors： Bozec A,Formento P,Fischel JL,Etienne-Grimaldi MC,Milano G

更新日期：2010-03-01 00:00:00